Post-Doctoral Fellow position available at the University of Colorado Denver. The University of Colorado Denver l Anschutz Medical Campus seeks individuals with a demonstrated commitment to creating an inclusive learning and working environment.

Nature of Work

The Proenza and Bankston laboratories in the Department of Physiology and Biophysics at the University of Colorado Anschutz Medical campus seek creative, independent, and motivated postdoctoral scientists for NIH-funded projects to study HCN ion channel biophysics and the physiology of cardiac pacemaking.

Exciting high-impact studies await first authors! Projects in the lab follow from our recent identification of two novel HCN4 channel interacting proteins (Peters et al., 2020, PNAS). A few of the questions to be answered include: What domains on the channels and the proteins determine the interactions? What is the affinity? What are the mechanisms of action? How do the two homologous interacting proteins exert opposing effects on the channels? What determines their specificity for the HCN4 isoform? Do the proteins co-localize with HCN4 in cardiac pacemaker cells? What effects do they have on heart rate regulation? Is the decline in maximum heart rate with age caused by downregulation of these proteins?

Techniques include patch clamp electrophysiology, quantitative biochemistry, proteomics, structural biology, confocal microscopy, and mathematical modeling. Training is available and all resources are in place for rapid progress.

Examples of Work Performed

This Post-Doctoral Fellow at the University of Colorado Denver will perform the duties like these

• Contribute to experimental design
• Acquire and analyze data
• Troubleshoot protocols and equipment and develop new techniques as required
• Prepare figures and write manuscripts for publication in top journals
• Apply for postdoctoral fellowships
• Present work at national and international meetings
• Contribute to collaborative projects in the labs

Minimum Requirements

• PhD in physiology, biophysics, or related field.
• Expertise and first author publications in at least one of the following areas: patch clamp electrophysiology, biochemistry, structural biology, or proteomics.
• Knowledge of basic principles of ion channel biophysics.

Competencies

• Self-motivated, creative problem solver.
• Strong work ethic and highest ethical standards.
• Excellent oral and written communication skills.
• Ability to work both independently and as a member of a collaborative team.

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